Complement-ARIE NAMs Reduction to Practice Challenge

Recent technological advances have set the stage for a renewed focus on human-based solutions called new approach methodologies (NAMs) that can complement, and in some cases replace, animal models in research and regulatory testing. These NAMs generally span advanced cell-tissue-organoid (in vitro), computational modeling (in silico), and cell-free biochemical analysis (in chemico) techniques, with each type of NAM offering different advantages. A combination and integration of multiple NAMs elements into a synergistic approach that augments gaps and/or deficiencies in individual NAMs approaches is a “combinatorial NAM” and could ultimately allow for improved predictions of human clinical response. Although many combinatorial NAMs are still early in development, not validated and standardized, nor available to the market broadly, combinatorial NAMs can potentially transform the way biomedical research, drug development, and clinical trials are conducted. To accelerate development and validation of combinatorial NAMs for human-based scientific and regulatory purposes, the National Institutes of Health (NIH) Common Fund’s Complement-Animal Research In Experimentation (Complement-ARIE) program in collaboration with the Food and Drug Administration (FDA) and Environmental Protection Agency (EPA), is launching the Reduction to Practice (RTP) Challenge. This challenge invites innovative combinatorial NAMs solutions from multidisciplinary teams who can successfully demonstrate implementation of their human-based solution in a practical and usable form within a 3-year period. Solvers will have the chance to win up to $1,430,000 in cumulative cash prizes and have their solution provided validation and/or qualification support by the Complement-ARIE Validation and Qualification Network (VQN). This Challenge is open to the public. 

Award: $7,000,000 in total prizes

Open Date: Phase 1 – September 30, 2025, Phase 2 – July 2, 2026; Phase 3 – August 1, 2027

Close Date: Phase 1 – March 1, 2026

For more information, visit: https://www.herox.com/Complement-ARIE-RTP

About The Author

Ben

I am the owner of Cerebral-overload.com and the Verizon Wireless Reviewer for Techburgh.com. My love of gadgets came from his lack of a Nintendo Game Boy when he was a child . I vowed from that day on to get his hands on as many tech products as possible. My approach to a review is to make it informative for the technofile while still making it understandable to everyone. Ben is a new voice in the tech industry and is looking to make a mark wherever he goes. When not reviewing products, I is also a 911 Telecommunicator just outside of Pittsburgh PA.

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